New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides
New sulfonated Cy3 and Cy5 phosphoramidites and solid supports were synthesized. These building blocks were used in the synthesis of terminally or internally labeled oligodeoxynucleotides. Mild deprotection schemes were applied to the sulfocyanine-labeled oligonucleotides.
Keywords: Oligonucleotides; controlled pore glass; deprotection; fluorescent label; indocyanines; phosphoramidites
Document Type: Research Article
Publication date: 01 January 2009
- Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
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