Oxidation of Flavan-3-Ols: Gram-Scale Synthesis of Taxifolin
Benzylic oxidation of catechine has been performed using either DDQ or Ce(IV) trifluoromethanesulfonate as oxidizing agent. These procedures allowed the efficient synthesis of taxifolin 3 in a high overall yield.
Keywords: NMR; Proanthocyanidins; alkylation reactions; hemisynthesis; pentabenzylated catechin
Document Type: Research Article
Affiliations: Unite de Phytopharmacie et Mediateurs Chimiques, Inra, Route de Saint-Cyr 78026 Versailles Cedex, France.
Publication date: 01 March 2006
- Letters in Organic Chemistry publishes original letters on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is placed on publishing quality papers very rapidly. Letters are processed rapidly and take full advantage of the Internet technology both for the submission and the review of the manuscripts.
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