Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1]
Tin (II) chloride dihydrate catalyses the nucleophilic ring opening of epoxide by aromatic amines leading to an efficient synthesis of β-amino alcohols in very good yields. The reactions are completely antistereoselective, highly regioselctive and proceed at ambient temperature which make this procedure particularly an alternative strategy for the synthesis of β-amino alcohols.
Keywords: Epoxides; aromatic amines; tin (II) chloride dihydrate (SnCl2.2H2O); β-amino alcohols
Document Type: Research Article
Affiliations: Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Publication date: 01 March 2006
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