Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents
5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and development of resistance particularly with metronidazole. For the development of new potentially safer derivatives, we investigated new strategies of synthesis: such as Vicarious
Nucleophilic Substitution of hydrogen (VNS), palladiumcatalyzed cross-coupling reactions (Suzuki-Miyaura, Sonogashira…) and electron transfer reactions (Unimolecular Radical Nucleophilic Substitution (SRN1), TDAE methodology) applied in 5-nitroimidazole series.
Keywords: 5-Nitroimidazole; Anti-infectious agents; Electron transfer reactions; Palladium-catalyzed reactions; VNS reaction
Document Type: Research Article
Publication date: 01 June 2014
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