Skip to main content

Predicting Drug Metabolism Induction In Silico

Buy Article:

$55.00 plus tax (Refund Policy)

The inducibility of drug-metabolizing enzymes and transporters by numerous xenobiotics has become a vital issue to be considered in the drug development process. Activation of so-called orphan nuclear receptors has been identified to result in increased expression of these detoxifying systems and consequently altered drug levels in the human body. In order to anticipate such mechanisms already in early stages of drug design and to avoid dangerous drug-drug interactions, reliable in silico simulation tools are highly desirable. This review aims to give an introduction into induction of drug metabolism and transport and focuses on computer-assisted molecular modeling prediction techniques, on their applicability and limitations, on recent case studies, and on success stories.





No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Nuclear receptors; in silico; metabolism induction prediction; molecular modeling

Document Type: Research Article

Affiliations: Institute of Pharmacy,Department of Pharmaceutical Chemistry, Innrain 52c, University of Innsbruck, A-6020 Innsbruck, Austria.

Publication date: 2006-08-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more