Does Isoform Diversity Explain Functional Differences in the 14-3-3Protein Family?
The 14-3-3 family of proteins was originally identified in 1967 as simply an abundant brain protein. However ittook almost 25 years before the ubiquitous role of 14-3-3 in cell biology was recognized when it was found to interactwith several signalling and proto-oncogene proteins. Subsequently 14-3-3 proteins were the first protein recognized tobind a discrete phosphoserine/threonine-binding motifs. In mammals the 14-3-3 protein family is comprised of seven ho-mologous isoforms. The 14-3-3 family members are expressed in all eukaryotes and although no single conserved func-tion of the 14-3-3s is apparent, their ability to bind other proteins seems a crucial characteristic. To date more than 300binding partners have been identified, of which most are phosphoproteins. Consequently, it has become clear that 14-3-3proteins are involved in the regulation of most cellular processes, including several metabolic pathways, redox-regulation,transcription, RNA processing, protein synthesis, protein folding and degradation, cell cycle, cytoskeletal organization andcellular trafficking. In this review we include recent reports on the regulation of 14-3-3 by phosphorylation, and discussthe possible functional significance of the existence of distinct 14-3-3 isoforms in light of recent proteomics studies. Inaddition we discuss 14-3-3 interaction as a possible drug target.
No Supplementary Data
No Article Media
Document Type: Research Article
Affiliations: Department of Biomedicine,University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Publication date: 01 June 2006
More about this publication?
- Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.