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Proteomic and Computational Methods in Systems Modeling of Cellular Signaling

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Cellular signaling lies at the core of cellular behavior, and is central for the understanding of many pathologicconditions. To comprehend how signal transduction is orchestrated at the molecular level remains the ultimate challengefor cell biology. In the last years there has been a revolution in the development of high-throughput methodologies inproteomics and genomics, which have provided extensive knowledge about expression profiles and molecular interaction-networks. However, these methods have typically provided qualitative and static information. This is about to turn, andseveral high-throughput methods are now available that provide quantitative and temporal information. These data arewell suited for analysis by computational methods and bioinformatics, which are becoming increasingly valuable tools tograsp the complexity of cellular networks. At present, several cellular pathways have been modeled in silico and theanalysis provides new understanding of the underlying properties that contribute to their dynamic features. Here, we re-view methodologies that are used for in silico modeling as well as methods to obtain large-scale quantitative data, and dis-cuss how they can be integrated to generate powerful and predictive models of cellular processes. We argue that the gen-eration of such models provide powerful tools to understand how systems properties emerges in healthy and pathologicstates, and to generate efficient strategies for pharmacological intervention.

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Keywords: Systems biology; cellular signaling; flow cytometry; mass spectrometry; proteomics; quantification; simulation

Document Type: Research Article

Affiliations: Department of Biomedicine,University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.

Publication date: 01 June 2006

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  • Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
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