Synthesis and Utilization of the Bis(>P(O)CH2)amine Derivatives Obtained by the Double Kabachnik–Fields Reaction with Cyclohexylamine; Quantum Chemical and X-Ray Study of the Related Bidentate Chelate Platinum Complexes
The microwave-assisted double Kabachnik–Fields (phospha-Mannich) reaction of cyclohexylamine, two equivalents of paraformaldehyde and >P(O)H species, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide affords the title compounds in good yields.
The bis(diphenylphosphinoxido) derivative was converted to the corresponding bidentate chelate platinum complex in two steps, whose stereostructure was elucidated by quantum chemical calculations. The crystal structure of the bidentate chelate complex was studied by X-ray analysis.
Keywords: Aminophosphonates; Bidentate Chelate Pt-Complexes; KabachnikāFields reaction; MW conditions; N, N-bis(phosphorylmethyl)amine derivatives; NMR Features; P-component; Ring Platinum Complex; X-ray crystallography; bidentate chelate platinum complex; bioactive substrates; ethyl phenyl-H-phosphinate; microwave (MW) technique; quantum chemical calculations; stereostructure
Document Type: Research Article
Publication date: 01 February 2012
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