Cyclodextrins to Increase the Utility of Enzymes in Organic Synthesis
The use of cyclodextrins to facilitate enzyme-catalysed processes is reviewed. The effects of the host molecules are discussed with specific attention paid to increasing the availability of insoluble substrates, reducing substrate inhibition and limiting product inhibition. In each case, the effects of the cyclodextrins are interpreted in terms of the formation of inclusion complexes. It is thus demonstrated that cyclodextrins can be used in a rational fashion to increase the utility of enzymes in organic synthesis.
Keywords: Aminocyclodextrin; Arthrobater globiformis; Chaperones; Crocus sativus; Cyclodextrins; Enzyme catalysed processes; Enzymes; Glucose 6 phosphate dehydrogenase; Linum flavum; Mucuna pruriens; Mycobacterium phlei; Mycobacterium smegmatis; Organic synthesis; Palmitoyl CoA; Penicillium raistrickii; Podophykllum hexandrum; Product inhibition; S phenylalanine ammonia; Selective guest binding; Stereoselective reduction; Substrate inhibition
Document Type: Review Article
Publication date: 01 April 2000
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