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Vitamin E does not Support Bone Quality in Orchidectomized Rats

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Vitamin E is known to improve antioxidant status, but the effect of vitamin E on bone quality in orchidectomized rats is unknown. In the present study, thirty-two 1-y-old male rats were randomized to two groups: a sham-control group (n=8) and an orchidectomized group (n=24). The orchidectomized group was divided into three groups of eight and assigned to one of the following treatments: orchidectomy (ORX), low-dose vitamin E of 65.6 mg/Kg diet or high-dose vitamin E of 656 mg/Kg diet. Four months after the study began, all rats were killed, blood was collected, and plasma was harvested for antioxidant status, tartrate resistant acid phosphatase (TRAP), and IGF-I. Orchidectomy decreased (P<0.05) plasma antioxidant and IGF-I, reduced bone (P<0.05) quality and bone strength, increased (P<0.05) plasma TRAP and urinary excretion of calcium and magnesium compared to the sham-control group. In contrast to ORX, vitamin E increased (P<0.05) plasma antioxidant and had no beneficial effect on indices of bone quality, bone resorption and bone formation marker, or urinary calcium and magnesium excretion. In conclusion, vitamin E appears to decrease oxidative stress without improving bone quality in orchidectomized rats.





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Keywords: Antioxidants; bone; oxidative stress; vitamin E

Document Type: Research Article

Publication date: 01 November 2007

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  • Current Nutrition & Food Science publishes frontier reviews on all the latest advances on basic and clinical nutrition and food sciences. The journal's aim is to publish the highest quality review articles dedicated to research in the field. The journal is essential reading for all nutrition and food scientists.
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