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Biosynthesis of Selenium Nanoparticle by Whole Cells of Saccharomyces boulardii and its Evaluation as Anticancer Agent

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Selenium is known to have cytoprotective role, which is important especially in reducing mortality due to cancer, a leading cause of death worldwide. The present work addresses synthesis and evaluation of selenium nanoparticles (SeNPs) as therapeutic alternative to conventional chemotherapeutic agents. Selenium nanoparticles were synthesized by an eco friendly method using whole cells of Saccharomyces boulardii. Parameters like culture age (stationary phase growth), cell mass concentration (100 mg/ml), temperature (35°C) and reaction time (72 h) were optimized to produce nanoparticle with controlled properties. Nanoparticles were recovered by alkali hydrolysis and subjected to UV-Vis spectroscopy, EDX (energy dispersive X-rays) analysis, electron microscopy, elemental analysis and size determination. Dynamic light scattering analysis reveals negative zeta potential value of 14.8 mV and PDI of 0.25. Experiments to prove possible involvement of sulfite reductase in nanoparticle formation has been carried out. Moreover, cytoprotective role of selenium nanoparticle has been shown by cell viability in MTT assay.
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Keywords: Cytoprotective; MTT assay; Saccharomyces boulardii; Selenium nanoparticle; Sulfite reductase

Document Type: Research Article

Publication date: 2013-08-01

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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