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Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives

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In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed.
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Keywords: Functionalization; amantadine; carboxylated multiwall carbon nanotubes; pregabalin and alendronate

Document Type: Research Article

Publication date: 01 August 2013

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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