Alzheimer´s Disease and Oxidative Stress: A Review
Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created
from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease
progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.
Keywords: Alzheimer disease; Fenton reaction; amyloid plaque; antioxidants; heavy metals; mitochondria; parkinson´s disease; reactive oxygen species; tau
Document Type: Research Article
Publication date: 01 January 2014
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