Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore
Keywords: Carbapenemases; guyana extended-spectrum-lactamase (GES); klebsiella pneumoniae carbapenemase (KPC); molecular interaction fields (MIFs); nonmetallo carbapanemase (NMC); pharmacophore prediction; serratia fonticola (SFC1); serratia marcescens (SME)
Document Type: Research Article
Publication date: 01 July 2016
- Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.