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Free Content Impact of Commonly Used Antidiabetic Drugs on Collagen Metabolites

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The objective of this research work is to investigate the effect of commonly used antidiabetic drugs such as Repaglinide, Pioglitazone, Glipizide and Metformin on collagen metabolites in healthy wistar albino rats. In this study 25% reduction in the activity of cathepsin D was observed in pioglitazone drug administered group when compared to control group. There was no change in the protein content and acid phosphatase enzyme level in the organs studied. Glycosaminoglycans (GAGs), hexosamine, and uronic acid content in the skin of animals treated with antidiabetic drugs showed significant changes (P < 0 01,P < 0 001) when compared to control group. The stress strain characteristics of the skin in normal and drug treated animals remain unaltered. The nativity (triple helical structure) of collagen is supported by Differential Scanning Calorimetry (DSC). Circular Dichroism (CD) study showed the intensity of positive and negative amide bands of collagen. The present study concludes the effect of antidiabetic drugs on collagen and its metabolites in wistar rats and this knowledge is useful and unique in the treatment of aging disease like diabetes.

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Keywords: ANTIDIABETIC DRUGS; CATHEPSIN D; CIRCULAR DICHROISM; COLLAGEN; METABOLITES

Document Type: Research Article

Publication date: 01 March 2014

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  • Journal of Pharmaceutical Sciences and Pharmacology is being launched to address the disconnect among different research areas related to pharmaceutical sciences and pharmacology. The extreme specialization has resulted in compartmentalization and complete segregation of disciplines related to pharmaceutical sciences. Relating a new development in drug delivery has become difficult to be noticed by the researchers in other related disciplines like the pharmacologists and/or clinicians. The aim of this journal is to publish high quality original research work and broad reviews in all related disciplines relevant to drugs under the same umbrella. Our expectation is that it will help the researchers, scholars and scientists to put their and others' work in the bigger context resulting in enhanced interdisciplinary and integrated research effort. The journal is intended to cover all disciplines and challenges in science, technology and engineering that contribute to the development of new improved drug molecules and their uses including pharmaceutical aspects.
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