Folate Conjugated Poly(ester amine) for Lung Cancer Therapy
Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.
Keywords: FOLATE RECEPTOR MEDIATED ENDOCYTOSIS; GENE DELIVERY; POLY(ESTER AMINE)
Document Type: Research Article
Publication date: 01 May 2010
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