Bioelectrochemical Sensing Based on Single Stranded Deoxyribonucleic Acid-Carbon Nanotubes Covalently Attached on Gold Electrodes
A biosensor based on single-stranded deoxyribonucleic acid-functionalized carbon nanotubes covalently attached to a self-assembled monolayer of 11-amino-1-undecanethiol on gold has been prepared. The preparation of the deoxyribonucleic acid sensor was followed using cyclic voltammetry. Single-walled carbon nanotubes, covalently attached to the gold surface present a nanoelectrode array behavior. To confirm the hybridization step between the probe and the target deoxyribonucleic acid, we used methylene blue, which is an indicator capable of distinguishing between single-stranded deoxyribonucleic acid and double-stranded deoxyribonucleic acid. Our results demonstrate that the modification of gold with single-walled carbon nanotubes and single-stranded deoxyribonucleic acid can be used for deoxyribonucleic acid hybridization detection.
Keywords: CARBON NANOTUBES; DNA; METHYLENE BLUE; NANOELECTRODE ARRAY; SELF-ASSEMBLED MONOLAYER
Document Type: Research Article
Publication date: 01 April 2009
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