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Design of Micro-Fluidic Bio-Reactors Using Topology Optimization

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Abstract:

We address the design of optimal reactors for supporting biological cultures using the method of topology optimization. For some years this method have been used to design various optimal microfluidic devices.1–4 We apply this method to distribute optimally biologic cultures within a flow of nutrition. From this optimized distribution alone the metabolic rate in the reactor increase by close to a factor 20.

Keywords: BIO-REACTORS; MICROFLUIDICS; TOPOLOGY OPTIMIZATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jctn.2007.016

Publication date: June 1, 2007

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  • Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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