PEG-Poly(amino acid)s/MicroRNA Complex Nanoparticles Effectively Arrest the Growth and Metastasis of Colorectal Cancer
One of the biggest challenges in developing microRNA (miRNA) based therapeutics is the method of delivery. Herein we report the design and synthesis of mPEG-poly(amino acid)s, which we used as a novel nanocarrier for the delivery of miRNA-139-5p. The PEG-poly(amino acid)s/miRNA-139-5p nanoparticle complex is more effective at suppressing tumor growth and migration in mice with colorectal cancer than when treated with miRNA-139-5p solution and blank nanoparticles individually. Our results suggest that PEG-poly(amino acid)s are a promising non-viral gene vector for the delivery of miRNAs to treat cancers.
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Document Type: Research Article
Publication date: 01 July 2016
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- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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