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Mitogen-Activated Protein Kinases and Mitochondrial Morphology and Bioenergetics

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Mitochondrial dynamics, i.e., fission, fusion, tubulation and transport, are vital for cell functioning. This holds in particular true for the nervous system where mitochondria need to be transported to synaptic endings to buffer calcium and provide energy for plasticity and intraneuronal communication. Mitogen-activated protein kinases (MAPK) such as ERK, p38, JNK and big ERKs, are not only major regulators of cellular proliferation and differentiation but also of mitochondrial structure, bioenergetics and mass. MAPK are tightly linked to mitochondria in several feedback loops that—apart from apoptotis—stabilize mitochondrial functioning and regulate mitochondrial dynamics. This review summarizes findings on the involvement of MAPK in pathological mitochondrial functioning and disturbed dynamics such as fission and fusion that might underly neurodegenerative disorders.
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Keywords: BCL-2; ERK; FISSION; FUSION; JNK; MAPK; MITOCHONDRIA; NEURODEGENERATION

Document Type: Review Article

Publication date: 01 June 2010

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  • This journal aims to focus specifically on the emerging new aspects of neuroprotection and neuroregeneration in the widest sense of neuroscience. American Journal of Neuroprotection and Neuroregeneration (AJNN) deals with research on all the aspects of the central nervous system: relevant CNS diseases, their processes and their modification with drugs that may have any influence and significance in experimental and clinical conditions.
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