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Potential Drug Interaction Between an Antiplatelet Agent and a Proton Pump Inhibitor

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Older adults frequently have multiple medical conditions and consequently receive multiple medications. Cardiovascular (CV) and gastrointestinal disorders are two conditions in seniors that often require both long-term antiplatelet therapy and medications for GI prophylaxis. Clopidogrel and pantoprazole are commonly used for these conditions; however, there are potential adverse consequences secondary to drug interactions. Both of these drugs are metabolized via the cytochrome P450 system, and there is a potential for drug interactions that may result in decreased effectiveness of clopidogrel and an increased risk of adverse CV outcomes. Pharmacists should be informed of these potential drug interactions and take appropriate actions to assure safe and effective patient care.
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Keywords: ANTIPLATELET; CLOPIDOGREL; DRUG INTERACTION; PANTOPRAZOLE; PROTON PUMP INHIBITORS

Document Type: Case Report

Affiliations: Long Island University (LIU) Pharmacy, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York, USA

Publication date: 01 October 2016

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  • The Consultant Pharmacist® is the official peer-reviewed journal of the American Society of Consultant Pharmacists. It is dedicated exclusively to the medication needs of the elderly in all settings, including adult day care, ambulatory care, assisted living, community, hospice, and nursing facilities. This award-winning journal is a member benefit of ASCP. Individuals who are not members and wish to receive The Consultant Pharmacist® will want to consider joining ASCP.
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