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Open Access An Integrative Approach to Hypertension: A Comprehensive Review of Antihypertensive Nutrients and Botanicals

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Objective: We conducted a comprehensive review of the most current data available on the antihypertensive effects of 29 different nutraceuticals.

Design: In this review, we collected evidence from clinical trials and meta-analyses of clinical trials with human subjects that are representative of the general adult population; studies of infants, children, and pregnant women were excluded. Observational studies were included in some cases as supplementary evidence, and in vitro or animal studies were included only for the purpose of explaining hypotensive mechanisms. PubMed served as the primary search engine.

Outcome measures: The efficacy of each nutrient and botanical was demonstrated by a treatment that resulted in a reduction of either systolic or diastolic blood pressure in humans.

Results: All of the reviewed botanical and nutrient supplements, with the exception of French maritime pine bark extract and maitake (Grifola frondosa), have been demonstrated to effectively lower blood pressure in humans with good tolerability.

Conclusions: Current data supporting the use of nutrients and botanicals in the treatment of blood pressure are encouraging.
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Keywords: Blood pressure; Botanicals; Hypertension; Minerals; Nutrients; Orthomolecular medicine; Vitamins

Document Type: Research Article

Publication date: 01 December 2016

More about this publication?
  • JRM is a peer-reviewed medical journal published annually by AARM. It publishes original research, reviews, and editorials that contribute to the understanding of nutritional and botanical influence on underlying mechanisms of chronic illness. The journal was established by MichaĆ«l Friedman, ND as the founding editor. The journal's current editor-in-chief is Liz Sutherland, ND of National University of Natural Medicine.
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