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Home / Journal of the American Association for Laboratory Animal Science, Volume 37, Number 5

Open Access Changes in Hematologic Values During Infection of New World Monkeys With Plasmodium falciparum and P. vivax

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Owl (Aotus sp.) and squirrel (Saimiri sp.) monkeys are used frequently in malaria vaccine trials, during which the animals are monitored daily for parasitemia and general well-being. Every 2 weeks, blood samples are taken, and hematology and chemistries are performed. We examined 97 cases of malarial infection in owl and squirrel monkeys, whose parasitemia increased by ≥ 22,000 parasites/uL daily during a 14-day interval. After malaria challenge, unprotected animals had significant changes in hematologic values. These changes could not be completely attributed to the increase in the parasite counts.

Document Type: Research Article

Publication date: 01 September 1998

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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