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Fate of Florfenicol in a Simulated Aquatic Ecosystem and Effects on Sediment Microflora

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Four controlled microcosms were prepared, one of which served as control, whereas the other three received treatments of 10, 50, and 150 mg/L of florfenicol, an antibacterial drug developed initially for aquaculture applications. Water and sediment samples were collected according to a pre-set time schedule to determine its fate in the aquatic environment. The results demonstrated that florfenicol amine was not detectable in any treatment groups. The half-life of florfenicol in pond water was 30.76, 52.92, and 51.48 hours for the 10, 50, and 150 mg/L treatment groups, respectively; the corresponding half-lives in sediment were 25.42, 38.40, and 53.59 days. Further, the 50 and 150 mg/L florfenicol treatment groups inhibited alkaline protease activity; however, all treatment groups inhibited sediment microflora structural diversity.
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Keywords: aquatic ecosystem model; florfenicol; florfenicol amine; sediment microflora

Document Type: Research Article

Publication date: 01 November 2012

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