Dimensioning a wastewater treatment plant (WWTP) using design guidelines requires a set of input factors. However, the information regarding these input factors might be very scarce during the initial stage of design. Therefore these input factors are usually associated with significant
uncertainty. In this study, global sensitivity analysis (GSA) is used to rank different uncertain input factors according to their influence on the uncertainty of the design variables. The pre-anoxic zone denitrification configuration (Ludzack and Ettinger, 1962) is selected as the case study
and the ATV design guideline (2000) is used for sizing the main design variables. The results of the GSA can help design engineers and decision makers in identifying the most important input factors and enable efficient spending of their resources to reduce the uncertainties associated with
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