Using Lines of Evidence to Determine Ecological Risk During an On-Going Risk Assessment of PPCPs: Cyclic Volatile Methyl Siloxanes as a Case Study
Abstract:Pharmaceutical and personal care products (PPCPs), a class of microconstituents, have gained increasing attention in recent years due to their increasing frequency of detection in the environment and over concerns of their long term effects. An on-going risk assessment for a certain class of PPCPs cyclic volatile methyl siloxanes (CVMS) will be discussed with special considerations for the unique physicochemical properties of CVMS materials. CVMS compounds undergo trophic dilution in aquatic foodwebs, due in part to their inefficient trophic transfer and metabolism in fish. The toxicity of CVMS compounds is described by the Target Lipid Model (TLM), which provides a framework for establishing conservative benchmarks for organic chemicals. Tissue residue concentrations of CVMS in biota are generally 1-2 orders of magnitude lower than the most conservative effects levels. These several complimentary lines of evidence (trophic dilution, tissue residue analysis) indicate that there are low ecological risks due to CVMS under the present-day emission conditions.
Document Type: Research Article
Publication date: 2010-01-01
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