Skip to main content

API Removal from Pharmaceutical Manufacturing Wastewater: Results of Full-Scale Wastewater Treatment Performance

Buy Article:

$9.50 plus tax (Refund Policy)

Or sign up for a free trial

Wyeth owns and operates an advanced industrial Wastewater Treatment Plant (WWTP) in Ireland. The facility is among the first full-scale pharmaceutical manufacturing sites to build and operate a wastewater treatment system specifically designed to remove Active Pharmaceutical Ingredients (APIs) from wastewater. The major unit processes at the WWTP include: (1) equalization and pH control; (2) biological treatment; (3) membrane filtration; and (4) ozone oxidation/degassing and destruction and discharge to a local Publicly Owned Treatment Works (POTW). Solids handing equipment includes screening of influent solids and thickening and centrifugation of waste activated sludge (biomass). This paper describes the process development work and then focuses on the full-scale performance of the treatment plant where: (1) estrogen APIs (17-α-estradiol; 17-β-estradiol (E2); 17-α-dihydroequilin; trimegestrone; estriol (E3); medrogestrone; norgestrel; and estradiol valerate) were removed to non-detectable levels; (2) estrogenicity was reduced from 3,843 ng/L to 3.16 ng/L, as 17β-estradiol equivalency; (3) the final effluent was shown to be non-toxic using the Microtox™ test; and; (4) the effluent is suitable for re-use as make-up water in cooling towers.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Data/Media
No Metrics

Keywords: API; MBR; Wastewater; endocrine disruptor; estrogen; estrogenicity; hormones; ozone; toxicity; treatment; wastewater re-use

Document Type: Research Article

Publication date: 2009-01-01

More about this publication?
  • Proceedings of the Water Environment Federation is an archive of papers published in the proceedings of the annual Water Environment Federation® Technical Exhibition and Conference (WEFTEC® ) and specialty conferences held since the year 2000. These proceedings are not peer reviewed.

    A subscription to the Proceedings of the Water Environment Federation includes access to most papers presented at the annual WEF Technical Exhibition and Conference (WEFTEC) and other conferences held since 2000. Subscription access begins 12 months after the event and is valid for 12 months from month of purchase. A subscription to the Proceedings of the Water Environment Federation is included in Water Environment Federation (WEF) membership.

    WEF Members: Sign in (right panel) with your IngentaConnect user name and password to receive complimentary access. Access begins 12 months after the conference or event
  • Subscribe to this Title
  • Membership Information
  • About WEF Proceedings
  • WEFTEC Conference Information
  • Learn about the many other WEF member benefits and join today
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more