This report builds on the third system review of the Consultative Group on International Agricultural Research (CGIAR), and is responsive to the challenges posed regarding food security, poverty, the environment, and genetic resources, within an integrated approach to the complex components of the overall challenge of feeding the world in the twenty first century. The combination of resources, and integrated approach, need to meet the complex aspects of the looming global crisis in food, and agriculture, and are presented within the CGIAR research agenda, which focuses on five principal challenges: increasing productivity, protecting the environment, preserving bio-diversity, improving policies, and strengthening national research. The report further examines the scientific breakthroughs that have the potential to radically reshape the world's agricultural, and food production. i.e., the gene revolution or bio-technology, natural resource management, and the information revolution. Recommendations suggest the need for a greater emphasis on governmental policy research, and reform; enhanced cooperation, and uncompromised objectives from the private sector; and, the need for partnerships in applying science to the problems of the poor. The second part features the history and function of the CGIAR, and its accomplishments.