One-electron redox reactions of trifluoperazine in aqueous solutions

Authors: Rele M.; Kapoor S.; Mukherjee T.

Source: Research on Chemical Intermediates, Volume 29, Number 6, 2003 , pp. 649-658(10)

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Abstract:

Absolute rate constants have been measured for the reactions of the primary and specific one-electron oxidant radicals with the protonated form of trifluoperazine (TFP). The primary radicals, e^-_aq and OH·, react with TFP at diffusion controlled rates. The transients thus produced have been characterized. Halogenated aliphatic peroxyl radicals oxidize TFP with rate constants between 10⁷ and 10⁸ dm³ mol^-1 s^-1, depending on the structure of the peroxyl radical. The reactivity of peroxyl radicals has been found to vary with Taft's inductive parameter. Oxidation of TFP at acidic pH has been studied using stopped-flow technique. The reaction between TFP radical cation and ascorbic acid has also been examined using pulse radiolysis technique. The results indicate that TFP radical cation is repaired by ascorbate. One-electron reduction potential of TFP · + /TFP at pH 3.5 has been calculated to be 0.964 V vs. NHE.

Keywords: TRIFLUOPERAZINE; PULSE RADIOLYSIS; HALOGENATED PEROXYL RADICAL; ELECTRON; TRANSFER.

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856703322539681

Publication date: 2003-10-01