Effects of amiloride and W-7 on the chemoreception of NaCl and KCl in the blowfly: implications for the salt quality

Authors: P.Solari, A. Liscia; Crnjar, R.

Source: Sensory Neuron, Volume 3, Number 2, 2000 , pp. 119-125(7)

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Abstract:

The role of amiloride in the labellar responses to various salt stimuli in the blowfly Protophormia terraenovae was studied with the aim of ascertaining whether salt reception is mediated by an amiloride-sensitive cation conductance. Results indicate that, unlike the case of NaCl, KCl sensitivity is inhibited by amiloride. W-7 (a calmodulin antagonist, involved in the Ca²⁺ cascade) strongly inhibits the chemosensillar response to both NaCl and KCl. Implications of transduction mechanisms for the 'salt' and 'water' chemoreceptors are discussed.

Keywords: 'SALT' RECEPTOR; 'WATER' RECEPTOR; BLOWFLIES; AMILORIDE; W-7

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856500744784

Affiliations: 1: Dipartimento di Biologia Sperimentale, Sezione di Fisiologia Generale, Università di Cagliari, Cittadella Universitaria, SS 554, Km 4,5, I-09042 Cagliari, Italy

Publication date: 2000-09-28

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