Authors: Bobryshev, P.; Bagaeva, T.; Filaretova, L.

Source: Inflammopharmacology, Volume 13, Numbers 1-3, 2005 , pp. 217-228(12)

Publisher: VSP, an imprint of Brill

Abstract:

The ability of glucocorticoid hormones to protect gastric mucosa during desensitization of capsaicin-sensitive afferent neurons has been investigated in rats. Functional ablation of the afferent neurons was performed by pre-treatment with neurotoxic doses of capsaicin (100 mg/kg s.c.). After 1 week of recovery, capsaicin-desensitized, as well as control rats were adrenalectomized or sham-operated. Seven days later, indomethacin at an ulcerogenic dose (35 mg/kg s.c.) was given to each group of rats. One half of adrenalectomized capsaicin-pre-treated rats were injected by corticosterone for replacement (4 mg/kg s.c., 15 min before indomethacin). Gastric lesions, plasma corticosterone and blood glucose levels were estimated 4 h after indomethacin administration. Indomethacin caused gastric erosions that were aggravated by adrenalectomy or desensitization of capsaicin-sensitive afferent neurons approximately with the same extension. Combination of adrenalectomy with the sensory desensitization profoundly potentiated the effect of sensory desensitization alone on indomethacin-induced gastric erosions: the mean gastric erosion area was increased approximately 10-fold. Corticosterone replacement completely prevented this profound effect of adrenalectomy. The results suggest a pivotal role of glucocorticoid hormones in the maintenance of gastric mucosal integrity in the case of impaired gastroprotective mechanisms provided by PGs and capsaicin-sensitive sensory neurons.

Keywords: GLUCOCORTICOIDS; CAPSAICIN-SENSITIVE NEURONS; GASTROPROTECTION; INDOMETHACIN; GASTRIC EROSIONS

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856005774423782

Affiliations: 1: Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg 199034, Russia

Publication date: 2005-08-01

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