Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata

Authors: Owoyele, Victor B.; Adediji, Joseph O.; Soladoye, Ayodele O.

Source: Inflammopharmacology, Volume 13, Numbers 5-6, 2005 , pp. 479-484(6)

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Abstract:

The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema was significantly reduced by all the doses of the extract administered, with the 200 mg/kg dose producing the highest oedema inhibition (80.5%). In the cotton pellet method, granuloma weight was significantly reduced from 14 ± 0.1 to 9.0 ± 0.1 mg, while in the formaldehyde induced arthritis the extract inhibited the oedema during the 10-day period. In conclusion, this study has established the anti-inflammatory activity of C. odorata and, thus, justifies the traditional uses of the plant in the treatment of wounds and inflammation.

Keywords: CHROMOLAENA ODORATA (L.); ANTI-INFLAMMATORY; OEDEMA; EXTRACT; RATS

Document Type: Short communication

DOI: http://dx.doi.org/10.1163/156856005774649386

Affiliations: 1: Department of Physiology and Biochemistry, University of Ilorin, Ilorin, P.M.B. 1515, Ilorin, Nigeria

Publication date: 2005-10-01