N,N-Dilauryl chitosan self-assembled vesicles for drug delivery

Authors: Li, Mingchun; Xin, Meihua

Source: Designed Monomers & Polymers, Volume 9, Number 1, 2006 , pp. 89-97(9)

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Abstract:

A novel kind of self-assembled vesicles for drug delivery has been prepared by N,N-dilauryl chitosan. The drug-release behavior of the vesicles can be changed by adjusting molecular weight of chitosan and adding additives, such as cholesterol. The drug-releasing rates of the vesicles made from larger molecular weight of chitosan are slower than that from smaller molecular weight of chitosan, and drug-releasing equilibrium amount as well. The additive can obviously raise the drug-releasing rates of the vesicles, especially for the vesicles made from larger-molecular-weight chitosan.

Keywords: N,N-DILAURYL CHITOSAN; LB FILM; SELF-ASSEMBLY; VESICLE; DRUG DELIVERY

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156855506775526179

Publication date: 2006-01-01