Authors: Zhou, Xueqin¹; Liu, Dongzhi²; Zhao, Tian²; Yao, Kangde³; Wang, Xueyan⁴; Wang, Lei⁴; Yang, Xinjian⁴

Source: Journal of Biomaterials Science, Polymer Edition, Volume 20, Number 4, 2009 , pp. 529-542(14)

Publisher: VSP, an imprint of Brill

Abstract:

The aim of this work was to evaluate the feasibility and efficacy of flexible adhesive electrodes (FAEs) prepared with adhesive matrices for iontophoretic delivery of baicalin, a drug used for the treatment of atopic dermatitis, viral hepatitis and HIV. Single-layer adhesive matrices (SLAMs) and double-layer adhesive matrices (DLAMs) were prepared from carbomer 940, sodium alginate and polyvinyl alcohol with appropriate mechanical and high baicalin release properties. During the direct-current (DC) iontophoresis with SLAM FAEs, electrochemical reaction caused a clear decrease of pH value at the interface IF_+,FCL and an increase of pH value at the interface IF_−,FCL. An additional pH-controlling layer in DLAMs could adjust the pH value of interfaces. Thus, deterioration of baicalin stability and the competitive delivery of hydroxyl ions produced with baicalin anions would be avoided during iontophoresis. Iontophoretic flux of baicalin from a DLAM FAE cathode increased proportionally to the time from the onset and affected by the current density and the frequency of pulsed DC. Increasing the applied current or the frequency could enhance the skin permeation flux of baicalin. Moreover, the baicalin skin permeation flux could be further improved from 0.22 μg/cm² per h in iontophoresis alone to 0.43 μg/cm² per h in the combined approach of iontophoresis and Azone^®.

Keywords: IONTOPHORESIS; TRANSDERMAL DELIVERY; ELECTRODE; ADHESIVE MATRIX; BAICALIN

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856209X416520

Affiliations: 1: School of Chemical Engineering, Tianjin Unviersity, Tianjin 300072, China; Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China 2: School of Chemical Engineering, Tianjin Unviersity, Tianjin 300072, China 3: Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China 4: Tianjin Changzheng Hospital, Tianjin 300021, China

Publication date: 2009-04-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Chemistry (General) ,  Engineering/Technology ,  Materials & Manufacturing
• By this author: Zhou, Xueqin ;  Liu, Dongzhi ;  Zhao, Tian ;  Yao, Kangde ;  Wang, Xueyan ;  Wang, Lei ;  Yang, Xinjian

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers