A nanosized, thermo-sensitive drug carrier: self-assembled Fe₃O₄-OA-g-P(OA-co-NIPAAm) magnetomicelles

Authors: Kim, Gwang-Chol¹; Li, Yong-Yong²; Chu, Yan-Feng²; Cheng, Si-Xue²; Zhang, Xian-Zheng²; Zhuo, Ren-Xi²

Source: Journal of Biomaterials Science, Polymer Edition, Volume 19, Number 9, 2008 , pp. 1249-1259(11)

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Abstract:

Novel thermo-sensitive magnetomicelles that consist of a magnetic core, Fe₃O₄-oleic acid (Fe₃O₄-OA), and an amphiphilic surface layer of thermo-sensitive poly(oleic acid-co-N-isopropylacrylamide) P(OA-co-NIPAAm) co-polymer were prepared. Fe₃O₄ magnetic cores functionalized with double bonds of oleic acid were prepared by suspension-oxidation reaction. Subsequently, by the co-polymerization of hydrophilic NIPAAm, hydrophobic OA and the Fe₃O₄-OA magnetic core, the thermo-sensitive amphiphilic polymers (P(OA-co-NIPAAm)) were grafted to obtain Fe₃O₄-OA-g-P(OA-co-NIPAAm) nanoparticles. The surface polymeric layer of Fe₃O₄-OA-g-P(OA-co-NIPAAm) nanoparticles would self-assemble in aqueous media to form a micellar structure attributed to the amphiphilic P(OA-co-NIPAAm) polymers. The model drug, prednisone acetate, was loaded in the magnetomicelles and in vitro release behavior of loaded drug in magnetomicelles was further investigated, which showed a thermo-sensitive release behavior due to the thermo-sensitive structural changes of the micellar surface layer.

Keywords: MAGNETOMICELLE; THERMO-SENSITIVE; CONTROLLED RELEASE

Document Type: Short communication

DOI: http://dx.doi.org/10.1163/156856208785540109

Affiliations: 1: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China; Institute of Polymer Science, Hamhung University of Chemical Technology, Hamhung, North Korea 2: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China

Publication date: 2008-09-01