@article {Bi:January 2008:0920-5063:131, author = "Bi, Xiangdong", author = "Shi, Xiangyang", author = "Baker, James R.", title = "Synthesis, characterization and stability of a luteinizing hormone-releasing hormone (LHRH)-functionalized poly(amidoamine) dendrimer conjugate", journal = "Journal of Biomaterials Science, Polymer Edition", volume = "19", year = "January 2008", abstract = "Cancer targeting is crucial for cancer detection, therapy and targeted drug delivery. A dendrimer-peptide conjugate has been synthesized based on poly(amidoamine) dendrimer generation 5 (PAMAM G5) as a platform and a luteinizing hormone-releasing hormone (LHRH) peptide as a targeting moiety. The synthesized conjugate was fully characterized using nuclear magnetic resonance (NMR), UV-Vis spectrometry, reverse-phase high-performance liquid chromatography (RP-HPLC) and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. Further stability experiments showed that the synthesized conjugate was stable after 72-h incubation in phosphate-buffered saline (PBS) buffer (pH 7.4) at 37°C. The synthesized conjugate may find applications in biomedical targeting, gene delivery and imaging.", pages = "131-142(12)", url = "http://www.ingentaconnect.com/content/vsp/bsp/2008/00000019/00000001/art00010" doi = "doi:10.1163/156856208783227686" }