Synthesis and characterization of microparticles made of carboxymethyloxysuccinic-acid-modified PLA-PEG co-polymer

Authors: Zhang, Haiyue1; Chang, Li2; Zhang, Bin2; Li, Peng2; Wang, Min2; Yao, Kang De1; Yang, Jun3; Yao, Fanglian2

Source: Journal of Biomaterials Science, Polymer Edition, Volume 19, Number 1, 2008 , pp. 99-111(13)

Publisher: VSP, an imprint of Brill

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Abstract:

A novel tri-block co-polymer, HO2C-PLA-PEG-PLA-CO2H (co-polymer II), with polybasic carboxylic acids as the end-groups was synthesized and characterized by IR and 1H-NMR. Based on the successful synthesis of co-polymer II, water-soluble sodium salicylate and oil-soluble tetrandrine, used as model drugs, were loaded in the co-polymer microparticles prepared through a modified multiple emulsion method. The encapsulation efficiency and drug-releasing behaviour were also investigated. It is found that the microparticles of about 10 μm in size are porous and can be produced from co-polymer II in better encapsulation efficiency (up to 86.65% and 55.94%) compared to those made from PLA/PEG/PLA (co-polymer I) (77.50% and 44.01%). The drug-release behaviour of co-polymer II exhibits an extended continuous release behaviour and the initial burst was reduced obviously. The results show that such functionalised PLA/PEG/PLA carrier provides higher drug encapsulation efficiency and better profiles.

Keywords: POLYBASIC CARBOXYLIC ACIDS; BLOCK CO-POLYMER; MICROPARTICLE

Document Type: Research article

DOI: 10.1163/156856208783227677

Affiliations: 1: Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, P. R. China 2: Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China 3: Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China

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