Fabrication of a novel pH-sensitive glutaraldehyde cross-linked pectin nanogel for drug delivery

Authors: Chang, Cong¹; Wang, Zong-Chun¹; Quan, Chang-Yun²; Cheng, Han²; Cheng, Si-Xue²; Zhang, Xian-Zheng²; Zhuo, Ren-Xi²

Source: Journal of Biomaterials Science, Polymer Edition, Volume 18, Number 12, 2007 , pp. 1591-1599(9)

Publisher: VSP, an imprint of Brill

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Abstract:

A novel pH-sensitive nanogel based on pectin cross-linked with glutaraldehyde (PT-GA) was designed and synthesized for drug delivery. Transmission electron microscope observation shows that the nano-sized gel particles exhibit a spherical morphology. The optical absorbance study of nanogel suspension reveals its pH sensitivity. Cytotoxicity study shows that the nanogel has no apparent inhibitory effect on cells. The in vitro drug-release behavior of the drug-loaded nanogel particles in three kinds of media, i.e., simulated gastric fluid, simulated intestine fluid and simulated colon fluid, was studied. PT-GA nanogel exhibits a faster release at a high pH, and the release could be further accelerated in the presence of pectinolytic enzyme, indicating that the nanogel may be used for colon-specific drug delivery.

Keywords: NANOGEL; PH SENSITIVE; PECTIN; DRUG RELEASE

Document Type: Short communication

DOI: http://dx.doi.org/10.1163/156856207794761925

Affiliations: 1: Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430072, P. R. China; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China 2: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China

Publication date: 2007-12-01