Preparation and characterization of pH-sensitive hydrogel of chitosan/poly(acrylic acid) co-polymer

Authors: Shi L.; Yang L.; Chen J.; Pei Y.; Chen M.; Hui B.; Li J.

Source: Journal of Biomaterials Science, Polymer Edition, Volume 15, Number 4, 2004 , pp. 465-474(10)

Publisher: VSP, an imprint of Brill

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Abstract:

A pH-sensitive co-polymer hydrogel of chitosan/poly(acrylic acid) (CS/PAAc) was prepared by irradiating the aqueous solution mixture of chitosan and acrylic acid with 60Co gamma-ray irradiation. The effect of the composition of chitosan and AAc on the properties of the hydrogel, such as swelling ratio and pH-sensitivity, were determined. Fourier Transform Infrared (FT-IR) spectrometry was applied in the attenuated total reflectance (ATR) mode for analyzing the structure change of the hydrogels after the treatment in different pH buffer solutions.

Keywords: CHITOSAN; POLY ACRYLIC ACID; HYDROGEL; PH-SENSITIVITY

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856204323005316

Publication date: 2004-04-01

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