Recent developments of collagen-based materials for medical applications and drug delivery systems

Author: Panduranga Rao, K.

Source: Journal of Biomaterials Science, Polymer Edition, Volume 7, Number 7, 1996 , pp. 623-645(23)

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Abstract:

In this review, an attempt was made to summarize some of the recent developments in the application of collagen as a biomaterial and in drug delivery systems. The main applications covered include: collagen for burn/wound cover dressings; osteogenic and bone filling materials; antithrombogenic surfaces; and immobilization of therapeutic enzymes. Recently, collagen used as a carrier for drug delivery has attracted many researchers throughout the world. The use of collagen for various drug delivery systems has also been reviewed in this article. Collagen-based drug delivery systems include: injectable microspheres based on gelatin (degraded form of collagen); implantable collagen-synthetic polymer hydrogels; interpenetrating networks of collagen; and synthetic polymers collagen membranes for ophthalmic delivery. Recent efforts to use collagen-liposomal composites for controlled drug delivery, as well as collagen as controlling membranes for transdermal delivery, were also reviewed. In this review, the main emphasis was on the work done in our laboratory.

Document Type: Research article

DOI: http://dx.doi.org/10.1163/156856295X00526

Affiliations: 1: Biomaterials Division, Central Leather Research Institute, Adyar, Madras, India

Publication date: 1996-01-01