The development of polyanhydrides for drug delivery applications

Authors: Tamada, J.¹; Langer, R.¹

Source: Journal of Biomaterials Science, Polymer Edition, Volume 3, Number 4, 1992 , pp. 315-353(39)

Publisher: VSP, an imprint of Brill

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Abstract:

This paper reviews the development of the polyanhydrides as bioerodible polymers for drug delivery applications. The topics include design and synthesis of the polymer, physical properties, techniques to fabricate the polymer into drug delivery devices, evaluation of biocompatibility, and example applications of the polyanhydrides. Discussion of the interrelationship between the physical-chemical properties of the polyanhydrides, fabrication methods, and drug release rates is included. One section is devoted to a case study to provide a historical perspective of the development a polyanhydride-based drug delivery treatment from the conception of the idea to the final stages of human clinical trials. This section includes an outline of the extensive in vitro and in vivo testing that is necessary for development of a new material for biomedical applications.

Keywords: Polyanhydride; biodegradable polymer; drug delivery; controlled release

Document Type: Research article

DOI: 10.1163/156856292X00402

Affiliations: 1: Room E25-342, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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