Alzheimer's disease: from bench to bedside

Authors: Saeed, Mohammad; Frossard, Philippe M.; Parvez, Hasan S.

Source: Biogenic Amines, Volume 18, Numbers 3-6, 2004 , pp. 177-195(19)

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Abstract:

Alzheimer's disease (AD) is the most common cause of dementia worldwide. It causes major debility for the elderly with medical, social and economic implications. The pathology of AD was described in early twentieth century. Significant scientific progress has been made to date in understanding the pathophysiology and genetics as well as developing therapeutic strategies for slowing disease progression and providing symptomatic relief to AD patients. This chapter reviews these advances and explores the links, molecular genetics and cellular biology has provided us today to tackle this devastating disorder.

Keywords: ALZHEIMER'S; AMYLOID; TAU; APOLIPOPROTEIN E; GENETICS

Document Type: Research article

DOI: http://dx.doi.org/10.1163/1569391041501861

Publication date: 2004-06-01