If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Massive Hyperplasia of Marginal Zone B-cells with Clear Cytoplasm in the Lymph Node: A Case Report

$30.41 plus tax (Refund Policy)

Buy Article:


An enlarged axillary lymph node from a 63-year-old woman showed proliferating marginal zone B-cells arranged in a vague nodular pattern or in band-forming aggregates throughout the cortex. Marginal zone B-cells, which also infiltrated the adjacent fatty tissue, had round or slightly indented nuclei of medium size and a moderate amount of clear cytoplasm. Immunohistochemically, these cells were CD20+, CD79a+, Bcl-2 +, sIgD, CD5, CD10, CD21, CD23, CD45RO, Bcl-6 , and cyclin D. A portion of the cells were sIgM- and CD43-positive. The polytypic nature of these cells was demonstrated by immunohistochemistry and polymerase chain reaction. Systemic bacterial infection appears to be the cause of marginal zone B-cell hyperplasia. This unusual marginal zone B-cell hyperplasia should be differentiated from low-grade B cell lymphomas, and particularly from nodal marginal zone B-cell lymphomas.

Document Type: Research Article

DOI: http://dx.doi.org/10.1078/0344-0338-00471

Affiliations: 1: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan 2: Department of Pathology and Genetics, Aichi Cancer Center Hospital, Nagoya, Japan 3: Kurosu Hospital, Ujiie, Japan 4: Department of Pathology, Dokkyo University School of Medicine, Mibu, Japan

Publication date: October 1, 2003

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more