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Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis

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A 45-year old man presented with a slow-growing, unilateral beige testicular mass, with a diameter of 4 cm. The testosterone, FSH, LH, estradiol and βhCG serum levels were within normal limits, and there were no associated hormonal syndromes. The patient was treated with inguinal orchidectomy. Microscopically, the tumor was composed of nests of cells with large eosinophilic, slightly granular cytoplasm. There was only a mild degree of atypia and no mitotic activity. The tumor extended into the rete testis. There were intratumoral calcifications, and in the vicinity of the tumor, there was intratubular growth. Although this case is histologically similar to the three previously reported cases of clinically benign large cell calcifying Sertoli cell tumor of the testis with rete testis involvement, the current patient developed right sided para-aortic lymph node metastases 18 months after the initial diagnosis.

Keywords: Large cell calcifying Sertoli cell tumors; Sertoli cell tumor; Sex-cord stromal tumors; Tumor testis

Document Type: Miscellaneous


Affiliations: 1: Department of Surgical Pathology of the University Hospital Antwerp, Belgium 2: Department of Urology, Zottegem, Belgium 3: Department of Surgical Pathology of the St-Elisabeth Hospital, Zottegem, Belgium 4: Department of Surgical Pathology of the Academic Hospital of the Free University Brussels, Brussels, Belgium

Publication date: April 1, 2003

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