Primary Cerebral Anaplastic Large Cell Lymphoma Containing Abundant Reactive Histiocytes and Eosinophils: A Case Report and Literature Review

Authors: Chuang S-S.¹; Huang W.²; Lin C-N.¹; Chio C-C.³; Tsai T-C.⁴; Li C-Y.⁵; Shen C-H.²

Source: Pathology Research and Practice, Volume 197, Number 9, September 2001 , pp. 647-652(6)

Publisher: Urban & Fischer

Abstract:

Primary cerebral anaplastic large cell lymphoma (ALCL) is very rare. We report on our experience with such a case and review the literature. A 46-year-old Taiwanese woman presented with headache, weakness of her right extremity, and limited eye movement. A solid mass (5cm × 4cm) at the left occipital lobe was almost completely removed. The neoplastic cells, some of which had reniform or embryo-like nuclei, were large and were admixed with abundant eosinophils, histiocytes, and some small lymphocytes. These neoplastic cells expressed CD30, CD43, granzyme B and T-cell intracellular antigen-1, but not ALK1, CD3, CD20, CD45, CD79a, cytokeratin, and EMA. They were positive for Epstein-Barr virus-encoded mRNA by in situ hybridization. Polymerase chain reaction study of formalin-fixed tissue showed a clonal gene arrangement of the T-cell receptor- chain. ALCL of T-cell lineage with cytotoxic phenotype was diagnosed. The patient received cranial irradiation and has remained with no evidence of disease for 25 months of follow-up.

Keywords: Anaplastic large cell lymphoma; CD30; Primary central nervous system lymphoma

Language: English

Document Type: Miscellaneous

DOI: http://dx.doi.org/10.1078/0344-0338-00140

Affiliations: 1: Departments of Pathology, Chi-Mei Foundation Hospital, National Cheng-Kung University, Tainan, Taiwan 2: Department of Medical Technology, School of Medicine, National Cheng-Kung University, Tainan, Taiwan 3: Departments of Neurosurgery, Chi-Mei Foundation Hospital, National Cheng-Kung University, Tainan, Taiwan 4: Departments of Radiology, Chi-Mei Foundation Hospital, National Cheng-Kung University, Tainan, Taiwan 5: Department of Pathology and Laboratory Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

Publication date: 2001-09-01

• In this: publication
• By this: publisher
• In this Subject: Pathology
• By this author: Chuang S-S. ;  Huang W. ;  Lin C-N. ;  Chio C-C. ;  Tsai T-C. ;  Li C-Y. ;  Shen C-H.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers