A Case of Esophageal Sarcomatoid Carcinoma with Molecular Evidence of a Monoclonal Origin

Authors: Kashiwabara K.1; Sano T.1; Oyama T.1; Najahima T.1; Makita F.2; Hashimoto N.2; Iwanami K.2; Kawashima O.2; Matsumoto T.3; Matsuzaki Y.3

Source: Pathology Research and Practice, Volume 197, Number 1, January 2001 , pp. 41-46(6)

Publisher: Urban & Fischer

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Abstract:

A case of polypoid tumor of the esophagus consisting of a sarcomatous tumor partly covered with superficial squamous cell carcinoma is described. The sarcomatous component consisted of anaplastic spindle and pleomorphic tumor cells that mimicked malignant fibrous histiocytoma (MFH). Both the sarcomatous and carcinomatous components were positive for p53 immunohistochemically. Further molecular analysis revealed that the two components had the same somatic mutation in the p53 gene. These results suggest a monoclonal origin of this biphasic tumor.

Keywords: Esophagus; Carcinosarcoma; Point mutation of the p53 gene

Language: English

Document Type: Miscellaneous

Affiliations: 1: Second Department of Pathology, Gunma University, School of Medicine, Gunma, Japan 2: Surgery, National Nishi-Gunma Hospital, Gunma, Japan 3: Internal Medicine, National Nishi-Gunma Hospital, Gunma, Japan

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