Antibodies to factor XII: a possible predictive marker for recurrent foetal loss
Authors: Jones D.W.1, 2; Gallimore M.J.1; Winter M.1
Source: Immunobiology, Volume 207, Number 1, February 2003 , pp. 43-46(4)
Publisher: Urban & Fischer
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Abstract:
Antibodies to factor XII (FXIIabs) have been demonstrated in some patients with the anti-phospholipid syndrome (APS). The presence of these antibodies were shown to lead to statistically significantly reduced levels of FXII (p=0.02). In an extension to this study forty female patients with either primary APS (n=26) or systemic lupus erythematosus (APS positive) (n=14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty one of the forty patients had a history of foetal loss (>2, mean=2.6). Lupus anticoagulant positivity showed a weak association with foetal loss (odds ratio=1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio=5.4, p=0.025).
Language: English
Document Type: Original article
DOI: 10.1078/0171-2985-00207
Affiliations: 1: Kent Haemophilia Centre, Kent and Canterbury Hospital, Kent, UK 2: Department of Biosciences, University of Kent at Canterbury, Canterbury, UK
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