The Role of Long-Lived Plasma Cells in Autoimmunity

Authors: Arce S.¹; Cassese G.¹; Hauser A.¹; Dörner T.²; Odendahl M.¹; Manz R.¹; Radbruch A.¹; Hiepe F.²

Source: Immunobiology, Volume 206, Number 5, December 2002 , pp. 558-562(5)

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Abstract:

Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.

Language: English

Document Type: Original article

DOI: http://dx.doi.org/10.1078/0171-2985-00204

Affiliations: 1: German Rheumatism Research Center, Berlin 2: Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charité, Humboldt University Berlin, Germany

Publication date: 2002-12-01