Do Chemokines Spark Autoimmunity in Juvenile and Adult Rheumatic Disease?

Authors: Mangge H.¹; Vojinovic J.²; Schauenstein K.³

Source: Immunobiology, Volume 206, Number 4, October 2002 , pp. 459-471(13)

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Abstract:

The recent increase in knowledge on chemokines contributes substantially to the understanding of autoimmune inflammatory diseases, as cell migration is an essential prerequisite for the local immune reaction. The purpose of this review is to summarize the essential functions of chemokines in immune activation and to examine their role(s) in the initiation and perpetuation of autoimmunity in juvenile idiopathic arthritis and adult rheumatic disease. The possible relevance of chemokines as therapeutical targets will be discussed.

Language: English

Document Type: Original article

DOI: http://dx.doi.org/10.1078/0171-2985-00194

Affiliations: 1: Department of Laboratory Medicine and Department of Pediatrics – Immunology/Rheumatology Unit, University of Graz, Austria 2: Pediatric Clinic, University Hospital Nis, Serbia, Yugoslavia 3: Department of Pathophysiology University of Graz, Austria

Publication date: 2002-10-01