Retrograde transport of cholera toxin into the ER of host cells

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Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.

Document Type: Research Article


Affiliations: GI Cell Biology, Children's Hospital Boston, the Harvard Digestive Diseases Center, and the Department of Pediatrics Harvard Medical School, Boston, MA, USA

Publication date: April 1, 2004

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